Anastrozole belongs to a class of drugs known as aromatase inhibitors; these drugs block aromastase (an enzyme) that is a major source of estrogen (a female hormone) in body.
Anastrozole is typically given to patients with breast cancer to reduce hormone blood levels that contribute to tumor growth, but it may be particularly helpful for men whose infertility is associated with abnormal levels of hormones (testosterone and estrogen).
Common side effects associated with the use of anastrozole include headache, diarrhea, nausea, back pain, weakness, and reduced energy.
ORIGINAL USES (ON-LABEL)
Advanced breast cancer in postmenopausal women with the disease progression following tamoxifen therapy, early ER-positive breast cancer in postmenopausal women, locally advanced or metastatic breast cancer (estrogen receptor-positive of hormone receptor unknown) in postmenopausal women.
NEWLY DISCOVERED USES (OFF-LABEL)
Infertility (male & female), McCune-Albright syndrome.
POTENTIAL SIDE EFFECTS
Vasodilation (widening of blood vessels), pain, headache, depression, hot flashes, weakness, arthritis, muscle aches, sore throat, peripheral edema (swelling related to fluid retention),
high blood pressure, weight gain, increased cough, bone pain, chest pain, pelvic pain, rash, hair loss, itching, high cholesterol levels, vomiting, constipation, abdominal pain, urinary tract infection,
vulvovaginitis, vaginal bleeding, anemia, various blood disorders, increase in liver function tests, blood clots, osteoporosis, fracture, cataracts.
- Inform your doctor if you have increased cholesterol levels; total cholesterol and LDL-cholesterol increases have occurred.
- A reduction in bone mineral density may occur.
- Safety and efficacy in premenopausal women has not been established.
Black cohosh, hops, natural licorice, red clover, thyme, dong quai
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category D. Excretion in breast milk unknown. Consult your doctor.
ARIMIDEX AND FEMALE INFERTILITY
During infertility treatment, ovarian stimulation with drugs is used either alone or in conjunction with intrauterine insemination and reproductive technologies.
At present, the two main medications for ovarian stimulation include clomiphene citrate and injectable gonadotropins.
In spite of the high ovulation rate with the use of clomiphene citrate, the pregnancy rate is much lower. In clomiphene citrate failures, gonadotropin injections have generally been used as the next treatment option.
Treatment with gonadotropins is difficult to control and characteristically associated with increased risk of multiple pregnancies.
Therefore, it would be preferable to use an effective oral treatment without risk of multiple pregnancies and with minimal monitoring.
Aromastase inhibitors, such as anastrozole, can be administered early in the follicular phase (time during menstrual bleeding) to induce ovulation.
Success of aromastase inhibitors like anastrozole in induction and augmentation of ovulation in addition to improving ovarian response to gonadotropin stimulation has been reported.
There are other potential applications for aromastase inhibitors in infertility management, including improving implantation in assisted reproduction and in-vitro maturation.
ARIMIDEX AND MALE INFERTILITY
Overall, researchers have noted that hormonal drugs for male infertility have had minimal success with the exception of aromatase inhibitors like anastrozole. In clinical trials, the testosterone-to-estradiol (a female hormone also present in men) ratio levels in infertile men improve with anastrozole. Use of Arimidex also causes semen changes that improve fertility. Two researchers with Cornell University Medical School studied 140 infertile men with abnormal hormone levels, and evaluated the effects of testolactone (an anticancer drug) daily or anastrozole daily. Men who received testolactone had increases in testosterone - to - estradiol ratios, sperm concentration, sperm motility, and improved in sperm structure. Treatment with Arimidex resulted in similar improvements in male-to-female hormone ratios, semen volume, sperm concentration, and sperm motility. Researchers concluded that anastrozole provides similar effects on hormones and semen as testolactone, and can help men who are infertile due to abnormal hormone ratios.
Buy Arimidex online
Where can I buy Arimidex without prescription?
Anastrozole is a prescription drug that comes in 1 mg tablets.
It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Anastrozole without prescription.
You may be able to order Arimidex from them online and save the local pharmacy markup.
Whether I can pay my Anastrozole order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, American Express (Amex), Wire transfers.
Is the Arimidex purchase legal?
Yes, it is legal. You confirm, that buy Arimidex tablets only for personal use without the purposes of resale.
All medicines are solved for application in the majority of the countries.
Generic Arimidex should pass any customs house, including American, without problems.
If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Anastrozole order.
If I'm buying Anastrozole online for the first time?
If you are buying Arimidex without prescription for the first time, start with a small amount to make sure that it works for you and then order more later.
Buy Anastrozole online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Arimidex at a reduced cost.