Cyproheptadine is an antihistamine medication that provides relief of seasonal and nonseasonal allergy symptoms such as watery and itchy eyes, runny nose and sneezing.
It is also used to relieve itching and hives due to some skin conditions.
Cyproheptadine reportedly has been effective in some patients for the management of migraines.
It is more commonly prescribed to children, as it has been shown to be only slightly effective in adults.
ORIGINAL USES (ON-LABEL)
Common seasonal and year-round allergies, use with other drugs to manage allergic type reactions.
NEWLY DISCOVERED USES (OFF-LABEL)
Autism, post-traumatic stress syndrome (PTSD)
POTENTIAL SIDE EFFECTS
Drowsiness, thickening of bronchial secretions, headache, tiredness, dizziness, increased appetite, nausea, diarrhea, dry mouth, muscle aches.
- Notify your doctor if you have narrow-angle glaucoma, prostate problems, bladder neck blockage, acute asthmatic attacks, gastrointestinal tract blockage, or a stenosing peptic ulcer.
- Avoid use in combination with MAO inhibitors.
- Not for use in children less than two years old.
- Elderly patients are at increased risk for side effects.
Other drugs that cause sedation (e.g., sedatives, anti-anxiety drugs, tranquilizers, narcotics, etc), MAO inhibitors (e.g., phenelzine, tranylcypromine, isocarboxazid.)
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Excretion in breast milk is unknown. Because newborns have an increased sensitivity to antihistamines and the potential for side effects is increased, do not breast-feed during therapy with this drug.
May cause drowsiness or dizziness, may interfere with tasks that require alertness.
Cyproheptadine is known as a sedating antihistamine, as it enters the brain in significant quantities and induces drowsiness. Researchers are unclear as to how it works to prevent migraines.
It is believed that since cyproheptadine also blocks serotonin, a chemical in the brain, that this has an effect in the prevention of migraines. The chemical, serotonin, is a factor in the cause of migraines.
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