DESCRIPTIONDesloratadine, the major active metabolite of loratadine, currently is approved by the FDA for use in patients with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. This drug is significantly more effective than placebo in reducing seasonal and perennial allergic rhinitis and chronic idiopathic urticaria symptoms, including nasal congestion. It appears to have a prompt onset of action in patients with seasonal allergic rhinitis and chronic urticaria. Clarinex also is safe and effective in patients with concomitant seasonal allergic rhinitis and mild to moderate asthma. How the efficacy of desloratadine compares with that of loratadine and other second-generation agents remains to be determined.
Desloratadine has a favorable safety profile. It is unlikely to cause somnolence and does not prolong the QTc interval or impair psychomotor performance or driving ability at recommended dosages. Clarinex appears to be less likely to interact with other drugs than fexofenadine.
ORIGINAL USES (ON-LABEL)
Relief of seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria symptoms.
POTENTIAL SIDE EFFECTS
Headache (14%), fatigue (5%), dizziness (4%), somnolence (2%), pharyngitis (4%); dry mouth (3%), nausea (5%); dyspepsia (3%), dysmenorrhea (2%).
CAUTIONS
- Increased intraocular pressure, hepatic disease, renal insufficiency.
- Not recommended for children under 12 years of age.
- Desloratadine passes into breast milk. Therefore, a decision should be made whether to discontinue breast-feeding or it, taking into account the importance of the drug to the mother.
- May be taken without regard to meals.
Azithromycin, erythromycin, fluoxetine, ketoconazole.
FOOD INTERACTIONS
Unknown
HERBAL INTERACTIONS
Unknown
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA pregnancy category C; use only if clearly needed.
SPECIAL INFORMATION
Desloratadine is classified in FDA pregnancy category C. Clarinex was not teratogenic in animals exposed to the equivalent of more than 200 times the exposure in humans at the recommended daily oral dosage. In a separate study, an increase in preimplantation loss and a decreased number of implantations and fetuses were noted in female animals given the equivalent of approximately 120 times the exposure in humans at the recommended daily oral dosage. Reduced body weight and slowed righting reflex were reported in pups at doses equivalent to at least 50 times the exposure in humans at the recommended daily oral dosage. Desloratadine had no effect on pup development at oral doses equivalent to approximately seven times the exposure in humans at the recommended daily dosage. However, there are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, desloratadine should be used during pregnancy only if clearly needed.
Buy Clarinex online
Where can I buy Clarinex without prescription?Desloratadine is a prescription drug that comes in 5 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Desloratadine without prescription. You may be able to order Clarinex from them online and save the local pharmacy markup.
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Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.
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Yes, it is legal. You confirm, that buy Clarinex tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Clarinex should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Desloratadine order.
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What is Desloratadine?
Clarinex is approved for the relief of the nasal and nonnasal symptoms of allergic rhinitis (seasonal and perennial) in patients 12 years of age and older. It also is indicated for the symptomatic relief of pruritus and reduction in the number and size of hives in patients with chronic idiopathic urticaria.
Clarinex is approved for the relief of the nasal and nonnasal symptoms of allergic rhinitis (seasonal and perennial) in patients 12 years of age and older. It also is indicated for the symptomatic relief of pruritus and reduction in the number and size of hives in patients with chronic idiopathic urticaria.
BRAND NAME
Aerius, Clarinex
GENERIC NAME
Desloratadine
CHEMICAL CLASS
Piperidine derivative
THERAPEUTIC CLASS
Antihistamine, 2nd generation
Aerius, Clarinex
GENERIC NAME
Desloratadine
CHEMICAL CLASS
Piperidine derivative
THERAPEUTIC CLASS
Antihistamine, 2nd generation
AVAIL FORMS
Tablets — Oral 5 mg.
Tablets — Oral 5 mg.
DOSAGE
Adult and Child >12 yr
PO 5 mg qd.
In patients with liver or renal impairment, a starting dose of 5 mg qod is recommended.
Orally disintegrating tablets should be placed on the tongue and may be administered with or without water.
Adult and Child >12 yr
PO 5 mg qd.
In patients with liver or renal impairment, a starting dose of 5 mg qod is recommended.
Orally disintegrating tablets should be placed on the tongue and may be administered with or without water.