DESCRIPTION
Nexium is indicated for the treatment of erosive gastritis (damage to lower esophagus by acid reflux from stomach), moderate to severe heartburn, and reduction in reoccurance of duodenal ulcers. It acts by inhibiting proton pumps (hydrogen ion) in the stomach. This inhibition reduces the amount of acid produced by the stomach.

ORIGINAL USES (ON-LABEL)
Gastroesophageal reflux disease (GERD), severe erosive esophagitis; treatment of active duodenal ulcers in combination with antiinfectives for Helicobacter pylori infection

MECHANISM OF ACTION
Irreversibly inactivates proton pump in gastric parietal cells, which blocks the final step in secretion of hydrochloric acid; acid secretion is inhibited until additional enzyme is synthesized; inhibits basal and stimulated gastric acid secretion.

POTENTIAL SIDE EFFECTS
The most common side effects are headache (5%), diarrhea, nausea, flatulence (gas) abdominal pain and constipation.

CAUTIONS
  • Contraindicated with hypersensitivity to omeprazole, esomeprazole, or other proton pump inhibitor.
  • Use cautiously with hepatic dysfunction, pregnancy, lactation.
DRUG INTERACTIONS
  • Drugs dependent on gastric pH for bioavailability (eg, ketoconazole, iron salts, digoxin). Absorption of these drugs may be affected.
  • Increased esomeprazole serum levels: flurazepam, triazolam.
  • Increased bleeding: warfarin.
  • Decreased diazepam clearance resulting in increased diazepam serum concentrations.
PREGNANCY AND BREAST-FEEDING CAUTIONS
Pregnancy category B; likely to be excreted into breast milk, use caution in nursing mothers (suppression of gastric acid secretion is potential effect in nursing infant, clinical significance unknown).

SPECIAL INFORMATION
  • Take the drug at least 1 hr before meals. Swallow the capsules whole; do not chew or crush. If you cannot swallow the capsule, it can be opened and sprinkled in applesauce or mixed in tap water, orange or apple juice, or yogurt; do not crush or chew the pellets. This drug will need to be taken for 4–8 wk, at which time your condition will be reevaluated.
  • Report severe headache, worsening of symptoms, fever, chills, darkening of the skin, changes in color of urine or stool.

    • Buy Nexium

    Where can I buy Nexium without prescription?
    Nexium is a drug that comes in 20 mg and 40 mg capsules. It is available on prescription only as capsules for oral use, but the online drugstore, will sell Esomeprazole without prescription. You may be able to order Nexium from them online and save the local pharmacy markup.

    Whether I can pay my Nexium order by Credit Card?
    Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.

    Is the Nexium purchase legal?
    Yes, it is legal. You confirm, that buy Esomeprazole only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Nexium Drug should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Nexium order.

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    Buy generic Nexium online after comparing prices to your local pharmacy and you'll agree - any online pharmacy can sell you Nexium medication at a reduced cost.










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    What is Nexium?
    BRAND NAME
    Nexium

    GENERIC NAME
    Esomeprazole

    CHEMICAL CLASS
    Benzimidazole derivative

    THERAPEUTIC CLASS
    Antiulcer agent; gastrointestinal antisecretory agent; Gastrointestinal/Proton Pump Inhibitor

    AVAIL FORMS
    Capsule — Oral 20 mg, 40 mg.
    DOSAGE
    Adult
    Healing of erosive esophagitis: PO 20-40 mg daily for 4-8 week; for patients who do not heal after 4-8 week, and additional 4-8 week of treatment may be considered.
    Maintenance of healing of erosive esophagitis: PO 20 mg every day.
    GERD: PO 20 mg every day for 4 wk; if symptoms do not resolve completely after 4 wk, an additional 4 week of treatment my be considered.
    Eradication of H. pylori: PO 40 mg daily in combination with amoxicillin 1 gm twice a day and clarithromycin 500 mg twice a day for 10 days (triple therapy).
    Dose adjustment in severe liver impairment: PO a dose of 20 mg every day should not be exceeded.