DESCRIPTION
Premarin is an estrogen and is indicated for the treatment of moderate to severe vasomotor symptoms flushing, hot flashes) associated with menopause, vaginal or vulvar atrophy, and prevention of osteoporosis.

WHAT IS ESTROGENS?
A group of steroid hormones, including oestradiol (estradiol), oestriol (estriol), and oestrone (estrone), that control female sexual development, promoting growth and function of the female sex organs and female secondary sex characteristics (such as breast development and growth of pubic hair). Estrogens are synthesized mainly by the ovaries; small amounts are produced by the adrenal glands, testes, and placenta. Naturally occurring estrogens and conjugated estrogens (mixtures of natural estrogens obtained from the urine of pregnant mares) are used mainly to treat a deficiency of these hormones (resulting in lack of sexual development and absence of periods) and symptoms of the menopause. Estrogens are also used to treat some menstrual disorders and certain types of prostate and breast cancer.

ORIGINAL USES (ON-LABEL)
Menopause, breast cancer (inoperable, in postmenopausal women and men), prostatic cancer, dysfunctional uterine bleeding, hypogonadism, castration, primary ovarian failure, atrophic vaginitis, prevention of osteoporosis.

POTENTIAL SIDE EFFECTS
Anxiety, blood clots in the blood vessels, breakthrough bleeding and spotting, breast pain, tenderness or enlargement, changes in sex drive, depression, disturbance in liver function, dizziness, fatigue, gall bladder disease, gut disturbances, such as nausea, abdominal pain, bloating, flatulence, indigestion, headache/migraine, irregular brown patches on the skin, usually of the face, leg cramps, premenstrual-like symptoms, rise in blood pressure, skin reactions such as rash and itch, steepening of corneal curvature which may make contact lenses uncomfortable, swelling of the ankles due to to fluid retention), vaginal thrush, weight changes.

CONTRAINDICATIONS
Breast cancer (except in selected patients being treated for metastatic disease), active thromboembolic disorders, known or suspected estrogen-dependent neoplasia, undiagnosed abnormal genital bleeding.

CAUTIONS
  • Hypertension, gallbladder disease, CHF, diabetes mellitus, depression, migraine headache, seizure disorders, hepatic disease, family history of breast or endometrial cancer, history of thromboembolic disorders, uterine fibroids, hypertriglyceridemia, hypercalcemia.
  • Hormone Replacement Therapy (HRT) should not be used by women who have cancer of the breast, uterus, or genital tract, thrombosis, or severe heart, liver, or kidney disease or by those who are pregnant or breastfeeding.
  • It should be used with caution by women who have had thrombosis or thromboembolism, migraine, diabetes, epilepsy, porphyria, fibroids, or tetanus. If pregnancy occurs HRT should be stopped immediately.
  • HRT may need to be discontinued before surgery.
DRUG INTERACTIONS
Tricyclic antidepressants, anticonvulsants, anticoagulants, oral hypoglycemics, tamoxifen, barbiturates, phenylbutazone, rifampin, corticosteroids, warfarin.

FOOD INTERACTIONS
Grapefruit juice.

HERBAL INTERACTIONS
St. John's wort, alfalfa, hops, saw palmetto, black cohosh, DHEA.

PREGNANCY AND BREAST-FEEDING CAUTIONS
Pregnancy category X; may decrease quantity and quality of breast milk.

SPECIAL INFORMATION
  • Use this drug cyclically or short term; prepare a calendar of drug days, rest days, and drug-free periods.
  • This drug cannot be given to pregnant women because of serious toxic effects to the baby.
  • Progestins recommended in non-hysterectomized women.
  • Premarin is derived from pregnant mare's urine; Cenestin from yams and soy. Although probably therapeutically equivalent, they are not substitutable by the pharmacist.
  • Consider topical products if treatment is solely for vulvar or vaginal atrophy.
  • Currently recommended that use of hormone replacement therapy be limited to treating symptomatic women, preferrably for ≤5 yrs. Risk felt to outweigh benefit in asymptomatic women using only for prophylaxis of other conditions.

    • Buy Premarin online

    Where can I buy Premarin without prescription?
    It is a prescription drug that comes in 0.625 mg tablets. Conjugated Estrogens are available on prescription only as tablets for oral use, but the online pharmacy, will sell it without prescription. You may be able to order Premarin from them online and save the local pharmacy markup.

    Whether I can pay my order by Credit Card?
    Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, American Express (Amex), Wire transfers.

    Is the Premarin purchase legal?
    Yes, it is legal. You confirm, that buy Estrogens only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Premarin should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your order.

    If I'm buying Premarin online for the first time?
    If you are buying Conjugated Estrogens without prescription for the first time, start with a small amount to make sure that it works for you and then order more later. Buy Premarin online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Premarin at a reduced cost.










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    What is Hormone Replacement Therapy?
    The use of female hormones to relieve the symptoms that occur when the ovaries cease to function, either naturally (the menopause) or following surgical removal of the ovaries ('surgical menopause').
    BRAND NAME
    Cenestin, Menest, C.E.S., Premarin

    GENERIC NAME
    Conjugated Estrogens

    CHEMICAL CLASS
    Estrogen derivative

    THERAPEUTIC CLASS
    Antineoplastic; antiosteoporotic; estrogen
    AVAIL FORMS
    Tablets — Oral 0.625 mg.
    DOSAGE
    Adult
    Menopause / atrophic vaginitis: PO 0.3-1.25 mg qd cyclically or continuously, with medroxyprogesterone in women with an intact uterus.
    Atrophic vaginitis: Vag cre 2-4 g qd cyclically, reduce dosage as tolerated (typically, 2-4 g once or twice weekly for maintenance).
    Osteoporosis prevention: PO 0.3-0.625 mg qd cyclically or continuously, with medroxyprogesterone in women with an intact uterus.
    Prostatic cancer: PO 1.25-2.5 mg tid.
    Breast cancer: PO 10 mg tid for 3 mo or longer.
    Castration / primary ovarian failure: PO 1.25 mg qd cyclically or continuously, with medroxyprogesterone in women with an intact uterus.
    Hypogonadism: PO 2.5 mg qd-tid cyclically, with medroxyprogesterone in women with an intact uterus.