NEWLY DISCOVERED USES (OFF-LABEL)
Diverticulitis, Meniere's Disease, otitis externa
ORIGINAL USES (ON-LABEL)
Injectable: Treatment of various bacterial infections, including bone infections, abdominal and urinary tract infections, respiratory tract infections, skin and soft tissue infection, endocarditis, septicemia. Topically: Treatment of skin and ocular infections.
Garamycin, Genoptic, Gentacidin, Gentak
Antibiotic (aminoglycoside — ophthalmic, topical, injectable).
This drug interferes with bacterial protein production by destroying the bacterial cell membrane.
POTENTIAL SIDE EFFECTS
Neurotoxicity (vertigo, ataxia), gait instability, ototoxicity (auditory and vestibular), nephrotoxicity, decreased creatinine clearance, edema, skin itching, reddening of skin, and rash.
- Inform your doctor if you are allergic to other drugs in this class (such as tobramycin, amikacin, kanamycin, etc.) or allergic to sulfites (which may be contained in some products).
- Injectable: Requires monitoring of kidney and hearing function and blood levels. May cause neurotoxicity. Elderly patients may be at higher risk of toxicities.
- Injectable: Is not intended to for long-term use due to toxicity.
- Prolonged use may result in superinfection or resistance.
- Avoid use in patients who have kidney insufficiency, vestibular or cochlear (ear) impairment, myasthenia gravis, low calcium levels, and conditions that depress neuromuscular transmission.
Injectable: penicillins, cephalosporins, amphotericin B, loop diuretics (e.g. furosemide tablets
, bumetanide), neuromuscular blocking drugs.
Topical, eye formulations: Do not use with other topical or eye formulations without consulting your doctor.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk. Consult your doctor.
Black box warning: Injectable drugs in this drug class have been associated with significant kidney or ear toxicity. Although kidney damage may be reversible, ear toxicity may not be reversible. Monitoring of levels and kidney function are required.
Topical: For external use only. Wash hands after application.
Eye Formulations (Cream, drops): Do not touch container to objects. May cause temporary stinging or blurring of vision after application. Consult doctor about contact lenses wear. Tilt head back to apply drops, place medication in eye and close eyes. Apply light finger pressure on tear gland for one minute after application.
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