DESCRIPTIONOxcarbazepine is an antiseizure drug approved for the treatment of epilepsy. It alters the pattern of neuronal firing and transmission of nerve impulses to prevent seizures.
Researchers in Spain sought to examine the efficacy of oxcarbazepine in patients diagnosed with chronic neuropathic pain. Forty people with a long history of neuropathic pain that was resistant to treatment with other medications such as other anticonvulsants, nonsteroidal anti-inflammatory drugs (NSAID), and opiates received Trileptal and then were evaluated by researchers. According to researchers, treatment with oxcarbazepine reduces symptomatic variations of neuropathic pain, especially in the case of lancinating discharges (a sensation of cutting, piercing, or stabbing) and burning pain, although the allodynia (pain from a source that is not normally painful) also improved with treatment. In 50% of cases the opinion of the patients themselves in response to treatment was good or very good. Researchers noted that the side effects included dizziness, drowsiness, and abdominal upsets, but they concluded that Trileptal has a good benefit-risk ratio and is a form of treatment that is well accepted by patients.
In another study, oxcarbazepine was tested in 36 people with neuropathic pain who were being treated with gabapentin, which did not give them relief from their pain. They were then given Trileptal in addition to gabapentin, and the results were excellent. Almost two thirds of the patients experienced pain relief, and their pain symptoms improved by more than 70%.
Another study involved 18 patients with neuropathic pain who had tried gabapentin but had not gotten relief. They were given oxcarbazepine, which caused a marked reduction in their pain. Pain reduction was rated as good in 33% of the patients and excellent in 39% of the patients. In a similar study, Trileptal was tested in 18 people whose pain was not relieved by gabapentin. In this study, 15 (83%) of the patients had good or excellent responses to oxcarbazepine, according to researchers.
Trileptal was also tested in 12 patients with neuropathic pain resulting from spinal cord injury. When they were treated with oxcarbazepine, 58% had moderate pain relief.
ORIGINAL USES (ON-LABEL)
To treat partial seizures in adults and children (4–16 years of age) with epilepsy.
NEWLY DISCOVERED USES (OFF-LABEL)
Chronic neuropathic pain, diabetic neuropathy, trigeminal neuralgia.
POTENTIAL SIDE EFFECTS
Headache, dizziness, somnolence, anxiety, uncoordinated gait, vertigo, insomnia, tremor, amnesia, emotional lability, nervousness, agitation, abnormal thinking, nausea, vomiting, abdominal pain, diarrhea, upset stomach, constipation, upper respiratory infection, double vision, uncontrolled eye movements, changes in taste sensation, fatigue.
CAUTIONS
- Low blood levels of sodium may occur; thus, it requires periodic monitoring during therapy.
- Do not abruptly stop this medication as it may increase the frequency of seizures.
- Notify your doctor if you have had previous allergies with carbamazepine, if you have reduced kidney function, or previous problems with low sodium.
- May have significant effects on cognitive function, including slowing, difficultly with concentration, and speech or language problems, fatigue, and coordination problems.
Phenytoin, phenobarbital, carbamazepine, phenytoin, valproic acid, verapamil, felodipine, oral contraceptives, calcium channel blockers, benzodiazepines, cyclosporine, pimozide, protease inhibitors, quinidine, sirolimus, and tacrolimus.
FOOD INTERACTIONS
Avoid alcohol, may increase central nervous system depression.
HERBAL INTERACTIONS
St John's wort, primrose, valerian, kava kava, gotu kola
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk. Do not breast-feed during therapy with this drug.
SPECIAL INFORMATION
Oral contraceptive may be less effective while you are taking this medication. Therefore, you will need to use a back-up form of birth control. In 2005, new information was added to the warnings and precautions of the product labeling regarding the risk of serious skin reactions in both children and adults. Discuss these potential risks with your doctor.
Buy Trileptal online
Where can I buy Trileptal without prescription?Oxcarbazepine is a prescription drug that comes in 150 mg, 300 mg, 600 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Oxcarbazepine without prescription. You may be able to order Trileptal from them online and save the local pharmacy markup.
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What is Trileptal?
This drug blocks sensitive sodium channels, inhibiting the repeated firing and release of neurotransmitters. Thus, it stabilizes seizure activity.
This drug blocks sensitive sodium channels, inhibiting the repeated firing and release of neurotransmitters. Thus, it stabilizes seizure activity.
BRAND NAME
Trileptal
GENERIC NAME
Oxcarbazepine
CHEMICAL CLASS
Dibenzazepine derivative
THERAPEUTIC CLASS
Anticonvulsant
Trileptal
GENERIC NAME
Oxcarbazepine
CHEMICAL CLASS
Dibenzazepine derivative
THERAPEUTIC CLASS
Anticonvulsant
AVAIL FORMS
Tablets — Oral 150 mg, 300 mg, 600 mg.
Tablets — Oral 150 mg, 300 mg, 600 mg.
DOSAGE
Adult
Monotherapy: initial: 300 mg bid; increase at 2 week intervals by up to 600 mg/day; maintenance 2400 mg/day.
Conversion from another antiepileptic drug (AED) initiate with 300 mg bid; simultaneously, reduction of the concomitant AED should begin; increase oxcarbazepine dose at weekly intervals (600 mg/day increments) to a maximum of 2400 mg/day in 2-4 weeks; terminate concomitant AED over 3-6 weeks; monitor closely.
Trigeminal neuralgia: 300 mg bid-qid; dosage increases weekly until pain control achieved; max 2400 mg/day.
Dosage in geriatric patients: Plasma conc and AUC 30-60% higher (presumable due to age-related reductions in creatinine clearance); initiate at low dosage and titrate slowly to response.
Adult
Monotherapy: initial: 300 mg bid; increase at 2 week intervals by up to 600 mg/day; maintenance 2400 mg/day.
Conversion from another antiepileptic drug (AED) initiate with 300 mg bid; simultaneously, reduction of the concomitant AED should begin; increase oxcarbazepine dose at weekly intervals (600 mg/day increments) to a maximum of 2400 mg/day in 2-4 weeks; terminate concomitant AED over 3-6 weeks; monitor closely.
Trigeminal neuralgia: 300 mg bid-qid; dosage increases weekly until pain control achieved; max 2400 mg/day.
Dosage in geriatric patients: Plasma conc and AUC 30-60% higher (presumable due to age-related reductions in creatinine clearance); initiate at low dosage and titrate slowly to response.