DESCRIPTION
Spironolactone belongs to a class of drugs called potassium-sparing diuretics. Diuretics are used to remove surplus fluid from the body’s bloodstream or tissues and are prescribed to treat hypertension. Spironolactone inhibits the hormone aldosterone, thus preventing salt retention and is used to treat advanced heart failure when symptoms persist after other drug therapies are maximized.

ORIGINAL USES (ON-LABEL)
Management of high blood pressure or edema associated with excessive aldosterone. Primary increased aldosterone levels, cirrhosis of the liver accompanied by edema or ascites, low potassium levels.

NEWLY DISCOVERED USES (OFF-LABEL)
Acne, congestive heart failure, familial male precocious puberty, hair loss in women, hirsutism, premenstruel dysphoric syndrome (PMDD), premenstrual syndrome (PMS), polycystic ovary syndrome.

POTENTIAL SIDE EFFECTS
Edema, drowsiness, lethargy, rash, hives, increased hair growth, breast swelling (men), breast pain (men), increased potassium levels, decreased sodium levels, anorexia, nausea, cramping, diarrhea, liver toxicity.

CAUTIONS
  • Notify your doctor if you have increased potassium levels, are pregnant, have kidney or liver impairment, taking other potassium sparing diuretics (such as triamterene, amiloride).
  • Avoid potassium supplements, potassium containing salt substitutes, a diet rich in potassium, or other drugs that can cause increased potassium levels.
  • Breast swelling is often related to dose and duration of therapy.
DRUG INTERACTIONS
Other potassium-sparing diuretics, potassium supplements, ACE inhibitors, angiotension receptor antagonists (ACE inhibitors), cotrimoxazole (high dose), salicylates, cholestyramine, digoxin, mitotane.

FOOD INTERACTIONS
Food increases absorption.

HERBAL INTERACTIONS
Avoid excessive ingestion of natural licorice.

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C/D. Enters breast milk. Consult your doctor.

SPECIAL INFORMATION
This drug has a black box warning regarding the development of tumors when administered for chronic periods in rats. Avoid unnecessary use of the product.

Spironolactone also seems to have antiandrogen potential and has been used to treat hormonal hair loss in women. A report from the University of Bologna, Italy in the Journal of the European Academic Dermatology and Venereology indicated that mild to moderate androgenetic alopecia in women responds to therapy with spironolactone with good results in many cases.

British Journal of Dermatology had a study from the University of Melbourne in Australia on the efficacy of oral antiandrogen therapy in women with female pattern hair loss. In an open study of 80 women aged 12 to 79 years, 40 received spironolactone and 40 received cyproterone. There were no significant differences in the results between the two drugs: 44% had hair regrowth; 44% had no change in hair density; and 12% had continuing hair loss. There was no pattern based on age, menopause status, hormone levels, clinical stage or other parameters, other than high midscalp clinical grade, which predicted a greater response.

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Where can I buy Spironolactone without prescription?
Spironolactone diuretic is a prescription drug that comes in 25 mg, 100 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Aldactone without prescription. You may be able to order Aldactone from them online and save the local pharmacy markup.

Whether I can pay my Spironolactone order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.

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Yes, it is legal. You confirm, that buy Aldactone tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Spironolactone should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Spironolactone order.

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What is Spironolactone?
This drug increases sodium chloride and water excretion while conserving potassium.
BRAND NAME
Aldactone

GENERIC NAME
Spironolactone

CHEMICAL CLASS
Aldosterone antagonist.

THERAPEUTIC CLASS
Antihypertensive (diuretic, potassium-sparing)
AVAIL FORMS
Tablets — Oral 25 mg, 100 mg.
DOSAGE
Adult
Edema or hypertension: PO 25-200 mg/day in single or divided doses.
Hypokalemia: PO 25-100 mg/day in single or divided doses CHF: PO 25 mg/day.
CHF: PO 25 mg/day.
Primary hyperaldosteronism diagnosis: PO 400 mg/day for 4 days (short test) or 4 wk (long test), then 100-400 mg/day maintenance.
Polycystic ovary disease or hirsutism: PO 100-200 mg/day.
Child
Diuretic or antihypertensive or ascites: PO 1-3 mg/kg/day in single or divided doses.