Topiramate is a new drug, belonging to a class called anticonvulsants. It is used in the treatment of epileptic seizures and in the prevention of migraine headaches.
Although how topiramate works is not fully understood, it modulates the neurotransmitter GABA in the brain. Side effects include dizziness, shakiness, rapid heartbeat, sweating, confusion, blurry vision, headache, and weakness. Serious side effects may include worsening of seizures, bleeding or bruising, chest pain, and trouble breathing.
ORIGINAL USES (ON-LABEL)
Used in combination to treat partial onset seizures and generalized tonic-clonic seizures, treatment of seizures associated with Lennox-Gastaut syndrome, prevention of migraines.
NEWLY DISCOVERED USES (OFF-LABEL)
Alcoholism (cravings and dependence), binge eating disorder, cluster headache treatment and prevention, cocaine addiction, diabetic neuropathy, essential tremor, fibromyalgia, multiple sclerosis, migraine prevention in children, neuropathy, psoriasis, post-traumatic stress disorder (PTSD), West syndrome.
POTENTIAL SIDE EFFECTS
Dizziness, muscle incoordination, drowsiness, insomnia, speech disorders, nervousness, uncontrolled movements of the eyes, numbness and tingling, memory impairment, tremor, confusion, difficulty concentrating, depression, language problems, agitation, aggressive reaction, emotional lability, abnormal gait, behavioral problems, rash, nausea, upset stomach, anorexia, abdominal pain, constipation, breast pain, weight loss, sinusitis, shortness of breath, blurred or double vision, fatigue, back pain, chest pain, flu-like syndrome, mood problems, increased sweating, loss of heat regulation resulting in increased body temperature.
- Report any sudden changes in vision to your doctor.
- Avoid abrupt withdrawal of topiramate and taper dose to minimize potential for increased seizure frequency.
- Notify doctor if you have liver or kidney impairment.
- Increase fluid intake to decrease risk of kidney stones.
- May cause numbness, sedation, psychomotor slowing, confusion, and mood disturbances.
Other central nervous system depressants (such as alcohol, narcotics, etc.) may increase sedative effects, acetazolamide
, phenytoin, antihistamines, cyclic antidepressants, antipsychotics, carbamazepine, digoxin, estradiol, valproic acid, oral contraceptives.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk and is not recommended during breast-feeding.
Contents of capsules may be sprinkled on a small amount of food (such as applesauce or custard). Swallow mixture immediately without chewing. Drink fluids immediately after ingesting to promote full swallowing. Do not save contents of capsule for future use.
Recent studies of topiramate suggest that it protects nerve cells against damage and so it has been studied in the treatment of multiple sclerosis (MS) in patients who experience paroxysmal symptoms (includes: trigeminal neuralgia, painful spasms, dysesthetic or paresthetic symptoms).
In one clinical trial involving 13 patients diagnosed with MS and paroxysmal symptoms, patients received an increasing dose of topiramate each week until they responsed optimally. Three patients did not complete the study due to severe and persistent dizziness and nausea. Neurophysiological (involving nerve stimulation) tests were performed prior to therapy onset and at 12 weeks to evaluate the effect of the drug on paroxysmal symptoms. All who completed the study responded to treatment, but none achieved regression. There was no distinct connection between the drug responses and increased doses. From the study, the evidence suggests that topiramate may be effective in those suffering from paroxysmal symptoms related to MS, and have tried other conventional therapies, but further studies are needed.
Buy Topamax online
Where can I buy Topamax without prescription?
Topiramate is a prescription drug that comes in 25 mg, 50 mg, 100 mg tablets.
It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Topiramate without prescription.
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Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.
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All medicines are solved for application in the majority of the countries.
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